Oxalyl chloride → HCID 10832459, compound

HRID 1066786Notes

Reaction equation

HRID 1066786 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1.[C:20](Cl)(=[O:24])[C:21]([Cl:23])=[O:22]>C(OCC)C>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:20](=[O:24])[C:21]([Cl:23])=[O:22])=[C:3]1[CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 211959852-[(4-Chlorophenoxy)methyl]-1-methyl-1H-indole

Product 1

HCID 10832459HCID 10832459, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-Methyl-2-(4-chlorophenoxymethyl)-1H-indole (1.00 g, 3.68 mmol), dissolved in 7.0 ml of diethyl ether in a round bottom flask under a nitrogen atmosphere. To the above solution was added oxalyl chloride (0.981 g, 7.73 mmol). The reaction mixture was stirred at room temperature for about 60 minutes. The progress of the reaction was monitored by thin layer chromatography.

Sources & evidence

ORD record
ord-ef91c36cee614ebc81337d7a16bcf015
Source dataset
uspto-grants-2001_06
Patent number
US06245761B1

Reaction notes

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