Sodium borohydride → HCID 21196206, compound

HRID 1066788Notes

Reaction equation

HRID 1066788 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11](=[O:26])[C:12]([N:14]2[CH2:19][CH2:18][CH:17]([N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH2:16][CH2:15]2)=[O:13])=[C:3]1[CH2:27][O:28][C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=1.[BH4-].[Na+]>C(O)C>[Cl:35][C:32]1[CH:33]=[CH:34][C:29]([O:28][CH2:27][C:3]2[N:2]([CH3:1])[C:10]3[C:5]([C:4]=2[CH:11]([OH:26])[C:12]([N:14]2[CH2:15][CH2:16][CH:17]([N:20]4[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]4)[CH2:18][CH2:19]2)=[O:13])=[CH:6][CH:7]=[CH:8][CH:9]=3)=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 106250041-[1,4′-Bipiperidin]-1′-yl-2-[2-[(4-chlorophenoxy)methyl]-1-methyl-1H-indol-3-yl]-1,2-ethanedione

Product 1

HCID 21196206HCID 21196206, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A round bottom flask under a nitrogen atmosphere was charged with 1-methyl-2-(4-chlorophenoxymethyl)-3-[2-[4-(piperidin-1-yl)piperidin-1-yl]-1,2-ethanedionyl]-1H-indole (0.1414 g, 0.282 mmol) and 2.8 ml of denatured ethanol. To this mixture was added sodium borohydride (0.064 g, 1.69 mmol). The reaction mixture was then stirred at room temperature overnight. The progress of the reaction was monitored by thin layer chromatography.

Sources & evidence

ORD record
ord-fb9944550bd6464ea7beb09ce6188552
Source dataset
uspto-grants-2001_06
Patent number
US06245761B1

Reaction notes

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