Formic Acid → HCID 21195990, compound

HRID 1066792Notes

Reaction equation

HRID 1066792 reaction equation
[Cl:1][C:2]1[CH:45]=[CH:44][C:5]([O:6][CH2:7][C:8]2[N:9]([CH2:17][CH2:18][CH:19]3[CH2:24][CH2:23][N:22](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH2:21][CH2:20]3)[C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:4][CH:3]=1.C(O)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]2[N:9]([CH2:17][CH2:18][CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:44][CH:45]=1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 21196110HCID 21196110, compound

Product 1

HCID 21195990HCID 21195990, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Under an argon atmosphere 2-[(4-chlorophenoxy)methyl]-1-[2-(1-tritylpiperidin-4-yl)ethyl]-1H-indole was dissolved in 7.0 ml of methylene chloride. The reaction solution was then placed on an ice bath and formic acid (0.3383 g) was added. The resulting mixture was stirred in the ice bath for about five hours. The progress of the reaction was monitored by thin layer chromatography.

Workup

  1. customThe reaction solution was then placed on an ice bath

Sources & evidence

ORD record
ord-7a7a1bfa43984058a33bb1fc3be89cb9
Source dataset
uspto-grants-2001_06
Patent number
US06245761B1

Reaction notes

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