2-(Bromomethyl)-4-chloro-1-fluorobenzene → 4-(2-fluoro-5-chlorobenzyloxy)-N-(t-butoxycarbonyl)-N-(isopropyl)butylamine

HRID 1066810Notes

Reaction equation

HRID 1066810 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH:11]([CH3:13])[CH3:12].FC1C=CC([Cl:34])=CC=1CBr>>[F:1][C:2]1[CH:24]=[CH:23][C:22]([Cl:34])=[CH:21][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]([C:14]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:15])[CH:11]([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 27736262-(Bromomethyl)-4-chloro-1-fluorobenzeneHCID 211960844-(2-fluorobenzyloxy)-N-(t-butoxycarbonyl)-N-(isopropyl)butylamine

Product 1

HCID 211960964-(2-fluoro-5-chlorobenzyloxy)-N-(t-butoxycarbonyl)-N-(isopropyl)butylamine

Procedure

The title intermediate was prepared essentially as described supra for 4-(2-fluorobenzyloxy)-N-(t-butoxycarbonyl)-N-(isopropyl)butylamine, except that an equimolar amount of 2-fluoro-5-chlorobenzyl bromide was employed instead of the 2-fluorobenzyl bromide employed therein.

Sources & evidence

ORD record
ord-419cf5eeae8145e2ae6b3639ea531da1
Source dataset
uspto-grants-2001_06
Patent number
US06245761B1

Reaction notes

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