Triethylamine → HCID 15512195, compound

HRID 1066881Notes

Reaction equation

HRID 1066881 reaction equation
[N:1]1([CH2:12][CH2:13][OH:14])[C:5]2[C:6]3[CH:11]=[CH:10][S:9][C:7]=3[CH2:8][C:4]=2[CH:3]=[N:2]1.C(N(CC)CC)C.[CH3:22][S:23](Cl)(=[O:25])=[O:24]>C(Cl)Cl>[CH3:22][S:23]([O:14][CH2:13][CH2:12][N:1]1[C:5]2[C:6]3[CH:11]=[CH:10][S:9][C:7]=3[CH2:8][C:4]=2[CH:3]=[N:2]1)(=[O:25])=[O:24]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 15512194HCID 15512194, compound

Product 1

HCID 15512195HCID 15512195, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 0.50 g of 2-(1,4-dihydrothieno[2′,3′:4,5]cyclopenta[1,2-c]pyrazol-1-yl)ethanol was dissolved in 15 ml of methylene chloride, 1.00 ml of triethylamine and 0.28 ml of methanesulfonyl chloride were added, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into ice water and extracted with chloroform. The organic layers were combined, washed with brine and then dried with anhydrous magnesium sulfate. After removal of the drying agent by filtration, the resulting filtrate was concentrated under a reduced pressure to give 0.75 g of 2-(1,4-dihydrothieno[2′,3′:4,5]cyclopenta[1,2-c]pyrazol-1-yl)ethyl methanesulfonate.

Workup

  1. extractionextracted with chloroform
  2. washwashed with brine
  3. dry with materialdried with anhydrous magnesium sulfate
  4. customAfter removal of the drying agent
  5. filtrationby filtration
  6. concentrationthe resulting filtrate was concentrated under a reduced pressure

Sources & evidence

ORD record
ord-bc6bdb03e3bf4723a471dfb3958a5422
Source dataset
uspto-grants-2001_06
Patent number
US06245796B1

Reaction notes

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