反应详情

A solution of 2.0 g of (1-benzhydryl-azetidin-3-yl)-(2-methoxyphenyl)-amine in 30 mL of methanol was added to a suspension of 10% Pd/C in methanol. 4.0 g of ammonium formate was added portion wise and the reaction was heated under reflux for 2 h. The mixture was cooled, filtered over celite, the filtrate was evaporated. The residue was triturated with CH2Cl2, and filtered. The filtrate was evaporated to give 0.840 g of the desired product.

1. temperaturethe reaction was heated
2. temperatureunder reflux for 2 h
3. temperatureThe mixture was cooled
4. filtrationfiltered over celite
5. customthe filtrate was evaporated
6. customThe residue was triturated with CH2Cl2
7. filtrationfiltered
8. customThe filtrate was evaporated