HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium formate → 3-(3-Fluorophenoxy)azetidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 1-Benzhydryl-3-(3-fluorophenoxy)azetidine | HCID 19799621 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(3-Fluorophenoxy)azetidine | HCID 15521974 | 67% |
Reaction Steps
A solution of 2.50 g of 1-benzhydryl-3-(3-fluoro-phenoxy)-azetidine in 10 mL of THF was added to a suspension of 10% Pd/C in methanol. Ammonium formate (4.6 g) were added portion wise and the reaction was heated under reflux for 3 h. The mixture was cooled, filtered through celite, and the filtrate was concentrated. The residue was triturated with CH2Cl2 and filtered. The filtrate was concentrated to give 0.840 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06245799B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-5711593f1aa94b75ac8b8f3ffe2c0d2e |
| Source note | uspto-grants-2001_06 |