反应详情

A solution of 2.50 g of 1-benzhydryl-3-(3-fluoro-phenoxy)-azetidine in 10 mL of THF was added to a suspension of 10% Pd/C in methanol. Ammonium formate (4.6 g) were added portion wise and the reaction was heated under reflux for 3 h. The mixture was cooled, filtered through celite, and the filtrate was concentrated. The residue was triturated with CH2Cl2 and filtered. The filtrate was concentrated to give 0.840 g of the desired product.

1. temperaturethe reaction was heated
2. temperatureunder reflux for 3 h
3. temperatureThe mixture was cooled
4. filtrationfiltered through celite
5. concentrationthe filtrate was concentrated
6. customThe residue was triturated with CH2Cl2
7. filtrationfiltered
8. concentrationThe filtrate was concentrated