反应详情

5-Methyl-hex-2-ynoic acid ethyl ester 7 (20.97 g) in THF (540 mL), pyridine (60 mL), and 5% Pd/BaSO4 (1.10 g) was hydrogenated in 3.25 hours. The solvent was evaporated, and the light oil was chromatographed on a silica gel coulmn. After recovering some unreacted acetylene, the olefin was eluted with 5% ether in pet ether to give pure fractions of (Z)-5-methyl-hex-2-enoic acid ethyl ester 8 (12.0 g).

1. customThe solvent was evaporated
2. customthe light oil was chromatographed on a silica gel coulmn
3. customAfter recovering some unreacted acetylene
4. washthe olefin was eluted with 5% ether in pet ether