反应详情

温度

-78 °C

n-Butyllithium (1.6 M solution in hexane, 34.85 mL, 55.76 mmol) was added to N-benzyltrimethylsilylmethylamine (10 g, 55.76 mmol) in dry THF (140 mL) and stirred at −78° C. under nitrogen atmosphere. After 45 minutes, methoxymethyl chloride (4.3 mL, 55.76 mmol) in THF (6 mL) was added and then stirred for another 3 hours. The THF was evaporated, and the residue was dissolved in hexane, washed with water, and dried over sodium sulfate. The solvent was evaporated to give under reduced pressure to give N-benzyl-N-(methoxymethyl)trimethylsilylmethylamine (10 g).

1. stirringstirred for another 3 hours
2. customThe THF was evaporated
3. dissolutionthe residue was dissolved in hexane
4. washwashed with water
5. dry with materialdried over sodium sulfate
6. customThe solvent was evaporated
7. customto give under reduced pressure