6-amino-4-methyl-2,3-benzoxazin-1-one → 6-[3-(1-Phenyl-cyclopropyl)-2-oxo-propionylamino]-4-methyl-2,3-benzoxazin-1-one

HRID 1066941Notes

Reaction equation

HRID 1066941 reaction equation
BrC1C=C(N[C:13](=[O:26])[C:14](=[O:25])[CH2:15][C:16]([CH3:24])([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])C=C2C=1COC2=O.[NH2:27][C:28]1[CH:29]=[CH:30][C:31]2[C:36](=[O:37])[O:35][N:34]=[C:33]([CH3:38])[C:32]=2[CH:39]=1.C1(C2(CC(=O)C(O)=O)CC2)C=CC=CC=1>>[C:18]1([C:16]2([CH2:15][C:14](=[O:25])[C:13]([NH:27][C:28]3[CH:29]=[CH:30][C:31]4[C:36](=[O:37])[O:35][N:34]=[C:33]([CH3:38])[C:32]=4[CH:39]=3)=[O:26])[CH2:17][CH2:24]2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 3

HCID 111829366-amino-4-methyl-2,3-benzoxazin-1-oneHCID 185512532-Oxo-3-(1-phenylcyclopropyl)propanoic acidHCID 185512614-Bromo-6-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide

Product 1

HCID 185511726-[3-(1-Phenyl-cyclopropyl)-2-oxo-propionylamino]-4-methyl-2,3-benzoxazin-1-one

Procedure

was obtained analogously to the process that is described for 4-bromo-6-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide from 6-amino-4-methyl-2,3-benzoxazin-1-one and 3-(1-phenyl-cyclopropyl)-2-oxo-propionic acid, melting point 197-200° C.

Workup

  1. customwas obtained analogously to the process that

Sources & evidence

ORD record
ord-747644c5fc924cf0a8044d07602435f4
Source dataset
uspto-grants-2001_06
Patent number
US06245804B1

Reaction notes

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