5-Aminophthalide → 5-[4-(4-Iodo-2-methoxyphenyl)-4-methyl-2-oxo-valeroylamino)-phthalide

HRID 1066943Notes

Reaction equation

HRID 1066943 reaction equation
BrC1C(NC(=O)C(=O)CC(C)(C2C=CC=CC=2)C)=CC=C2C=1COC2=O.[NH2:27][C:28]1[CH:29]=[C:30]2[C:35](=[CH:36][CH:37]=1)[C:33](=[O:34])[O:32][CH2:31]2.[I:38][C:39]1[CH:44]=[CH:43][C:42]([C:45]([CH3:53])([CH3:52])[CH2:46][C:47](=[O:51])[C:48](O)=[O:49])=[C:41]([O:54][CH3:55])[CH:40]=1>>[I:38][C:39]1[CH:44]=[CH:43][C:42]([C:45]([CH3:53])([CH3:52])[CH2:46][C:47](=[O:51])[C:48]([NH:27][C:28]2[CH:29]=[C:30]3[C:35](=[CH:36][CH:37]=2)[C:33](=[O:34])[O:32][CH2:31]3)=[O:49])=[C:41]([O:54][CH3:55])[CH:40]=1

Participants

4

Reactant 3

HCID 7206695-AminophthalideHCID 185511904-(4-Iodo-2-methoxyphenyl)-4-methyl-2-oxovaleric acidHCID 185512024-Bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide

Product 1

HCID 183506275-[4-(4-Iodo-2-methoxyphenyl)-4-methyl-2-oxo-valeroylamino)-phthalide

Procedure

was obtained analogously to the process that is described for 4-bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide from 5-aminophthalide and 4-(4-iodo-2-methoxyphenyl)-4-methyl-2-oxo-valeric acid as a foam.

Workup

  1. customwas obtained analogously to the process that

Sources & evidence

ORD record
ord-84cd79c664fa420c8714738e14e778d1
Source dataset
uspto-grants-2001_06
Patent number
US06245804B1

Reaction notes

Loading…