5-Aminophthalide → 5-[4-(4-Bromo-2-methoxyphenyl)-2-oxo-valeroylamino)-phthalide

HRID 1066946Notes

Reaction equation

HRID 1066946 reaction equation
BrC1C(NC(=O)C(=O)CC(C)(C2C=CC=CC=2)C)=CC=C2C=1COC2=O.[NH2:27][C:28]1[CH:29]=[C:30]2[C:35](=[CH:36][CH:37]=1)[C:33](=[O:34])[O:32][CH2:31]2.[Br:38][C:39]1[CH:44]=[CH:43][C:42]([CH:45]([CH3:52])[CH2:46][C:47](=[O:51])[C:48](O)=[O:49])=[C:41]([O:53][CH3:54])[CH:40]=1>>[Br:38][C:39]1[CH:44]=[CH:43][C:42]([CH:45]([CH3:52])[CH2:46][C:47](=[O:51])[C:48]([NH:27][C:28]2[CH:29]=[C:30]3[C:35](=[CH:36][CH:37]=2)[C:33](=[O:34])[O:32][CH2:31]3)=[O:49])=[C:41]([O:53][CH3:54])[CH:40]=1

Participants

4

Reactant 3

HCID 7206695-AminophthalideHCID 185511874-(4-Bromo-2-methoxyphenyl)-2-oxo-valeric acidHCID 185512024-Bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide

Product 1

HCID 211968205-[4-(4-Bromo-2-methoxyphenyl)-2-oxo-valeroylamino)-phthalide

Procedure

was obtained analogously to the process that is described for 4-bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide from 5-aminophthalide and 4-(4-bromo-2-methoxyphenyl)-2-oxo-valeric acid, melting point 136-140° C.

Workup

  1. customwas obtained analogously to the process that

Sources & evidence

ORD record
ord-7d9bf01768c549cbbaae2c3b5ef93be9
Source dataset
uspto-grants-2001_06
Patent number
US06245804B1

Reaction notes

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