2,2-Diphenylethylamine → HCID 131722639, compound

HRID 1067064Notes

Reaction equation

HRID 1067064 reaction equation
[C:1]([N:8]([CH3:34])[C@H:9]([C:31](O)=[O:32])[CH2:10][CH2:11][CH2:12][NH:13][C:14]([O:16][CH2:17][CH:18]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:24]2[C:19]1=[CH:20][CH:21]=[CH:22][CH:23]=2)=[O:15])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[C:35]1([CH:41]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH2:42][NH2:43])[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[C:44]1([CH:41]([C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[CH2:42][NH:43][C:31](=[O:32])[C@H:9]([CH2:10][CH2:11][CH2:12][NH:13][C:14]([O:16][CH2:17][CH:18]2[C:19]3[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:25]3[C:30]2=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:15])[N:8]([C:1]([O:3][C:4]([CH3:6])([CH3:7])[CH3:5])=[O:2])[CH3:34])[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=1

Participants

3

Reactant 2

HCID 775752,2-DiphenylethylamineHCID 122173709HCID 122173709, compound

Product 1

HCID 131722639HCID 131722639, compound

Procedure

Using Procedure A, Nα-Boc-Nδ-Fmoc-Nα-methylornithine and 2,2-diphenylethylamine afforded a colorless solid: 1H NMR (400 MHz, CDCl3) δ1.39 (s, 10H), 1.57 (m, 2H), 1.77 (m, 1H), 1.98 (m, 1H), 2.50 (s, 3H), 3.19 (m, 2H), 3.80 (m, 1H), 4.00 (m, 1H), 4.19 (t, J=9.5 Hz, 1H), 4.22 (m, 1H), 4.40 (d, J=7.2 Hz, 2H), 4.46 (m, 1H), 7.20-7.34 (m, 12H), 7.41 (t, J=6.6 Hz, 2H), 7.60 (d, J=8.0 Hz, 2H), and 7.79 (d, J=8.5 Hz, 2H).

Workup

  1. customafforded a colorless solid

Sources & evidence

ORD record
ord-5ebff82fb06c47fba07dc164fec35953
Source dataset
uspto-grants-2001_06
Patent number
US06245746B1

Reaction notes

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