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HRID1067098

反应详情

EQUATION

反应方程式

HRID 1067098 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)NCCC[C@H](NC(=O)OC(C)(C)C)C(=O)O
HCID7015803

BOC-ORN(BOC)-OH

C15H28N2O6

结构：CC(C)(C)OC(=O)NCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)Sc1ccc2ccccc2c1
HCID20662195

未命名化合物

PRODUCTS

生成物

1
结构：NCCC[C@@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)Sc1ccc2ccccc2c1.O=C(O)C(F)(F)F
HCID20662221

未命名化合物

PROCEDURE

实验过程

N-Boc-D-phenylalaninyl 2-naphthyl thioether was deprotected (Procedure E) to afford D-phenylalaninyl 2-naphthyl thioether trifluoroacetate which was coupled (Procedure B) with Nα,Nδ-bis-Boc-ornithine. The Nα,Nδ-bis-Boc-ornithyl-D-phenylalaninyl 2-naphthyl thioether was deprotected by exposure to trifluoroacetic acid to afford after HPLC purification the titled compound: 1H NMR (400 MHz, D2O) δ1.60-1.70 (4H), 2.64-2.70 (2H), 2.90-3.30 (3H), 3.41-3.50 (1H), 3.80-3.82 (1H), 4.39-4.41 (1H), 7.23-7.70 (8H), and 7.80-8.05 (4H); mass spectrum (relative intensity) m/e 408 (100, M+1).

WORKUP

后处理

  1. customto afford
  2. customafter HPLC purification the titled compound