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HRID1067116

反应详情

EQUATION

反应方程式

HRID 1067116 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)[O-].[NH4+]
HCID517165

Ammonium acetate

C2H7NO2

结构：O=C(CC1CCCCC1=O)OC(C(=O)c1ccccc1)c1ccccc1
HCID53903505

未命名化合物

PRODUCTS

生成物

1
结构：O=C1CCCCC1Cc1nc(-c2ccccc2)c(-c2ccccc2)o1
HCID13126831

2-[(4,5-Diphenyl-1,3-oxazol-2-yl)methyl]cyclohexan-1-one

C22H21NO2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

A mixture of ammonium acetate (6.3 g), acetic acid (30 ml) and 1,2-diphenyl-2-oxoethyl (2-oxocyclohex-1-yl)acetate (15.0 g) was heated under reflux for 2.5 hours. After used workup, the crude product was purified by column chromatography (silica gel 100 g, eluent; hexane:ethyl acetate=20:1 then 9:1 then 6:1) to give 2-[(4,5-diphenyl-oxazol-2-yl)methyl]cyclohexanone as an amorphous solid.

WORKUP

后处理

  1. temperaturewas heated
  2. temperatureunder reflux for 2.5 hours
  3. customthe crude product was purified by column chromatography (silica gel 100 g, eluent