HCID 54433463, compound → HCID 21196513, compound

HRID 1067128Notes

Reaction equation

HRID 1067128 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([C:18]3[CH:23]4[CH2:24][CH:20]([CH2:21][CH2:22]4)[C:19]=3[CH2:25][C:26]3[CH:27]=[C:28]([CH:32]=[CH:33][CH:34]=3)[C:29]([OH:31])=[O:30])[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Pd]>[C:1]1([C:7]2[N:8]=[C:9]([CH:18]3[CH:23]4[CH2:24][CH:20]([CH2:21][CH2:22]4)[CH:19]3[CH2:25][C:26]3[CH:27]=[C:28]([CH:32]=[CH:33][CH:34]=3)[C:29]([OH:31])=[O:30])[O:10][C:11]=2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 54433463HCID 54433463, compound

Product 1

HCID 21196513HCID 21196513, compoundYield 89.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 3-{[3-(4,5-diphenyloxazol-2-yl)bicyclo-[2.2.1]hept-2-en-2-yl]methyl}benzoic acid (0.3 g) and 10% Pd/C (0.1 g) in methanol (20 ml) was stirred under H2 for 8 hours. The catalyst was filtered off and filtrate was evaporated in vacuo to give 3-{[3-(4,5-diphenyloxazol-2-yl)-bicyclo[2.2.1]hept-2-yl]methyl}benzoic acid (0.27 g).

Workup

  1. filtrationThe catalyst was filtered off
  2. customfiltrate was evaporated in vacuo

Sources & evidence

ORD record
ord-7d9209b8b14d447e95308f15daf9e07c
Source dataset
uspto-grants-2001_06
Patent number
US06245790B1

Reaction notes

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