Thiophosgene → HCID 21192204, compound

HRID 1067178Notes

Reaction equation

HRID 1067178 reaction equation
[C:1](Cl)(Cl)=[S:2].[NH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]([CH2:17][C:18]([OH:20])=[O:19])[CH2:13][C:14]([OH:16])=[O:15])=[CH:8][CH:7]=1>C(Cl)(Cl)Cl>[N:5]([C:6]1[CH:11]=[CH:10][C:9]([CH:12]([CH2:17][C:18]([OH:20])=[O:19])[CH2:13][C:14]([OH:16])=[O:15])=[CH:8][CH:7]=1)=[C:1]=[S:2]

Participants

4

Reactant 2

HCID 10040ThiophosgeneHCID 14273590HCID 14273590, compound

Product 1

HCID 21192204HCID 21192204, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
40 °C

Procedure

11.5 g (100 mmol) of thiophosgene is added to 22.12 g (100 mmol) of 3-(4-aminophenyl)-glutaric acid in 300 ml chloroform and heated for 50 minutes at 40° C. It is evaporated to dryness and the residue is crystallized from a little isopropanol/ether.

Workup

  1. customIt is evaporated to dryness
  2. customthe residue is crystallized from a little isopropanol/ether

Sources & evidence

ORD record
ord-945f31b5a1cf4871baf879ee94d89b94
Source dataset
uspto-grants-2001_06
Patent number
US06248306B1

Reaction notes

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