HCID 15017873, compound → HCID 21192218, compound

HRID 1067179Notes

Reaction equation

HRID 1067179 reaction equation
[N+:1]([C:4]1[CH:38]=[CH:37][C:7]([O:8][CH2:9][CH:10]([OH:36])[CH2:11][N:12]2[CH2:23][CH2:22][N:21]([CH2:24][C:25]([OH:27])=[O:26])[CH2:20][CH2:19][N:18]([CH2:28][C:29]([OH:31])=[O:30])[CH2:17][CH2:16][N:15]([CH2:32][C:33]([OH:35])=[O:34])[CH2:14][CH2:13]2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH2:9][CH:10]([OH:36])[CH2:11][N:12]2[CH2:13][CH2:14][N:15]([CH2:32][C:33]([OH:35])=[O:34])[CH2:16][CH2:17][N:18]([CH2:28][C:29]([OH:31])=[O:30])[CH2:19][CH2:20][N:21]([CH2:24][C:25]([OH:27])=[O:26])[CH2:22][CH2:23]2)=[CH:37][CH:38]=1

Participants

4

Reactant 1

HCID 15017873HCID 15017873, compound

Product 1

HCID 21192218HCID 21192218, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

15 g (27.7 mmol) of 10-[3-(4-nitrophenoxy)-2-hydroxypropyl]-1,4,7-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane (EP 0485045 (Schering AG), Example 12a), is dissolved in 250 ml of methanol and 5 g of palladium catalyst (10% Pd on activated carbon) is added. It is hydrogenated overnight at room temperature. The catalyst is filtered off and the filtrate is evaporated to dryness in a vacuum.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate is evaporated to dryness in a vacuum

Sources & evidence

ORD record
ord-fee4d3803741445abf267b86b825b81d
Source dataset
uspto-grants-2001_06
Patent number
US06248306B1

Reaction notes

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