HCID 15017873, compound → HCID 21192218, compound

Participants

Reaction Steps

15 g (27.7 mmol) of 10-[3-(4-nitrophenoxy)-2-hydroxypropyl]-1,4,7-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane (EP 0485045 (Schering AG), Example 12a), is dissolved in 250 ml of methanol and 5 g of palladium catalyst (10% Pd on activated carbon) is added. It is hydrogenated overnight at room temperature. The catalyst is filtered off and the filtrate is evaporated to dryness in a vacuum.

Provenance & Evidence