HCID 178512658, compound → HCID 178479397, compound

HRID 1067224Notes

Reaction equation

HRID 1067224 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([S:12]([NH2:15])(=[O:14])=[O:13])=[CH:9][CH:10]=2)[C:5]([NH:16][C:17]([NH2:19])=[NH:18])=[N:4][CH:3]=1>CCO.Cl>[ClH:1].[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([S:12]([NH2:15])(=[O:14])=[O:13])=[CH:9][CH:10]=2)[C:5]([NH:16][C:17]([NH2:19])=[NH:18])=[N:4][CH:3]=1

Participants

4

Reactant 1

HCID 178512658HCID 178512658, compound

Product 1

HCID 178479397HCID 178479397, compoundYield 190%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

4-Chloro-1-guanidino-7-isoquinolinesulphonamide (30 mg, 0.10 mmol) was dissolved in a solution of EtOH saturated with HCl gas (2.0 mL) and the mixture stirred at room temperature for 1 h. The solvents were evaporated in vacuo and the residue was azeotroped with CH2Cl2 to give 4-chloro-1-guanidino-7-isoquinolinesulphonamide hydrochloride (32 mg, 0.095 mmol) as a white solid.

Workup

  1. customThe solvents were evaporated in vacuo
  2. customthe residue was azeotroped with CH2Cl2

Sources & evidence

ORD record
ord-d1a53640cbba4c6e9d192f1e69485b05
Source dataset
uspto-grants-2001_06
Patent number
US06248738B1

Reaction notes

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