Hydrochloric Acid → N-(3,4-dimethoxybenzyl)urea

HRID 1067248Notes

Reaction equation

HRID 1067248 reaction equation
Cl.[CH2:2]([NH2:13])[C:3]1[CH:12]=[CH:11][C:8]([O:9][CH3:10])=[C:5]([O:6][CH3:7])[CH:4]=1.[O-:14][C:15]#[N:16].[Na+]>O>[CH3:7][O:6][C:5]1[CH:4]=[C:3]([CH:12]=[CH:11][C:8]=1[O:9][CH3:10])[CH2:2][NH:13][C:15]([NH2:16])=[O:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 79832VeratrylamineHCID 517096Sodium Cyanate

Product 1

HCID 1484507N-(3,4-dimethoxybenzyl)urea

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

60 ml of 5n HCl were added at room temperature within 45 min to a solution of 49.5 ml (300 mM) of 90% veratrylamine and 20.40 g (307 mM) of 98% sodium cyanate in 500 ml of water. After stirring overnight the crystals were collected: 52.66 g (83.5%) of urea with a melting point of 172-3° C. (sublimation 157° C.).

Workup

  1. customwere collected
  2. customwith a melting point of 172-3° C. (sublimation 157° C.)

Sources & evidence

ORD record
ord-eede5f1cfd714b98aa79023edcead00c
Source dataset
uspto-grants-2001_06
Patent number
US06248746B1

Reaction notes

Loading…