Hydrochloric Acid → N-[(2H-1,3-Benzodioxol-5-yl)methyl]carbamimidic acid

HRID 1067249Notes

Reaction equation

HRID 1067249 reaction equation
Cl.[CH2:2]([NH2:12])[C:3]1[CH:11]=[CH:10][C:9]2[O:8][CH2:7][O:6][C:5]=2[CH:4]=1.[O-:13][C:14]#[N:15].[Na+]>O>[CH2:7]1[O:8][C:9]2[CH:10]=[CH:11][C:3]([CH2:2][NH:12][C:14]([NH2:15])=[O:13])=[CH:4][C:5]=2[O:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 75799Benzo-1,3-dioxole-5-methylamineHCID 517096Sodium Cyanate

Product 1

HCID 274953N-[(2H-1,3-Benzodioxol-5-yl)methyl]carbamimidic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

61.5 ml of 5N HCl was added within 30 minutes to a stirred emulsion of 38.51 ml (300 mM) of 97% piperonylamine and 20.40 g of sodium cyanate in 500 ml of water. After stirring overnight the foamy solid is collected, dried, suspended in 500 ml of ether and collected again: 52.57 g (90.2%) of urea with a melting point of 183-84° C.

Workup

  1. customis collected
  2. customdried
  3. customcollected again

Sources & evidence

ORD record
ord-5d196ce2ca3c4560a844eccbf93fc0bc
Source dataset
uspto-grants-2001_06
Patent number
US06248746B1

Reaction notes

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