Hydrazine hydrate (1:1) → 8-Amino-7-chloro-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

HRID 1067275Notes

Reaction equation

HRID 1067275 reaction equation
[NH2:1][C:2]1[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[C:5]([C:12](OCC)=[O:13])=[CH:4][C:3]=1[Cl:17].O.[NH2:19][NH2:20]>C(O)C>[NH2:1][C:2]1[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[C:5]([C:12]([NH:19][NH2:20])=[O:13])=[CH:4][C:3]=1[Cl:17]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 15817383Ethyl 8-amino-7-chloro-2,3-dihydro-1,4-benzodioxine-5-carboxylate

Product 1

HCID 158173848-Amino-7-chloro-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

38.4 g (0.149 mol) of ethyl 8-amino-7-chloro-2,3-dihydro-1,4-benzodioxine-5-carboxylate suspended in 150 ml of ethanol are introduced into a 1 l reactor, 149 g (2.98 mol) of hydrazine hydrate are added, over 15 min, and the mixture is refluxed for 1 h.

Workup

  1. additionare introduced into a 1 l reactor
  2. temperaturethe mixture is refluxed for 1 h.

Sources & evidence

ORD record
ord-d928594de4ab43698f047645651f5f0f
Source dataset
uspto-grants-2001_06
Patent number
US06248757B1

Reaction notes

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