HCID 131722669, compound → HCID 70180896, compound

HRID 1067276Notes

Reaction equation

HRID 1067276 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:23]2[O:27][C:26](=[O:28])[N:25]([C@H:29]3[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][CH2:36][CH2:37][C:38]([O:40]C)=[O:39])[CH2:30]3)[N:24]=2)[C:5]2[O:10][CH2:9][CH2:8][O:7][C:6]=2[C:11]=1[NH:12]C(OCC1C=CC=CC=1)=O>Cl>[NH2:12][C:11]1[C:6]2[O:7][CH2:8][CH2:9][O:10][C:5]=2[C:4]([C:23]2[O:27][C:26](=[O:28])[N:25]([C@H:29]3[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][CH2:36][CH2:37][C:38]([OH:40])=[O:39])[CH2:30]3)[N:24]=2)=[CH:3][C:2]=1[Cl:1]

Participants

3

Reactant 1

HCID 131722669HCID 131722669, compound

Product 1

HCID 70180896HCID 70180896, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

0.50 g (0.85 mmol) of methyl (S)-3-[5-[7-chloro-8-[[(phenylmethoxy)carbonyl]amino]-2,3-dihydro-1,4-benzodioxin-5-yl]2-oxo-2,3-dihydro-1,3,4-oxadiazol-3-yl]pyrrolidine-l-pentanoate dissolved in 5 ml of concentrated aqueous hydrochloric acid is placed in a 25 ml round-bottomed flask and the reaction medium is refluxed for 22 h.

Workup

  1. customis placed in a 25 ml round-bottomed flask
  2. temperaturethe reaction medium is refluxed for 22 h.

Sources & evidence

ORD record
ord-991e32b5270a4816be27e71bd48369a9
Source dataset
uspto-grants-2001_06
Patent number
US06248757B1

Reaction notes

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