Potassium Carbonate → HCID 21192921, compound

Participants

Reaction Steps

N-(8-Ethyl-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-4methoxy-3-trifluoromethylbenzamide (0.157 g) was dissolved in methanol/water (5:1 6 ml), potassium carbonate (0.228 g) added and the mixture stirred overnight. The mixture was partitioned between dichloromethane and water the organic phase separated and solvent removed at reduced pressure. The residue was column chromatographed (silica gel, ammonia/methanol/dichloromethane mixtures as eluant) to give the title compound (0.97 g)

Provenance & Evidence