Potassium Carbonate → HCID 21192921, compound

HRID 1067295Notes

Reaction equation

HRID 1067295 reaction equation
[CH2:1]([C:3]1[C:4]([NH:19][C:20](=[O:33])[C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[C:23]([C:29]([F:32])([F:31])[F:30])[CH:22]=2)=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][N:10](C(=O)C(F)(F)F)[CH2:9][CH2:8]2)[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH2:1]([C:3]1[C:4]([NH:19][C:20](=[O:33])[C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[C:23]([C:29]([F:30])([F:32])[F:31])[CH:22]=2)=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][NH:10][CH2:9][CH2:8]2)[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 21192929HCID 21192929, compound

Product 1

HCID 21192921HCID 21192921, compoundYield 774.6%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

N-(8-Ethyl-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-4methoxy-3-trifluoromethylbenzamide (0.157 g) was dissolved in methanol/water (5:1 6 ml), potassium carbonate (0.228 g) added and the mixture stirred overnight. The mixture was partitioned between dichloromethane and water the organic phase separated and solvent removed at reduced pressure. The residue was column chromatographed (silica gel, ammonia/methanol/dichloromethane mixtures as eluant) to give the title compound (0.97 g)

Workup

  1. customThe mixture was partitioned between dichloromethane and water the organic phase
  2. customseparated
  3. customsolvent removed at reduced pressure
  4. customchromatographed (silica gel, ammonia/methanol/dichloromethane mixtures as eluant)

Sources & evidence

ORD record
ord-719fd86819f44f60ba9713e25bc1e351
Source dataset
uspto-grants-2001_06
Patent number
US06248754B1

Reaction notes

Loading…