Methanol → 6212-32-4

HRID 1067471Notes

Reaction equation

HRID 1067471 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[C:10](=[O:13])([O-])[O-].[NH4+:14].[NH4+].[O-:16][C:17]#[N:18].[K+].CO>O>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]2[NH:14][C:17](=[O:16])[NH:18][C:10]2=[O:13])=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 887MethanolHCID 77264-ChlorobenzaldehydeHCID 517111Ammonium CarbonateHCID 11378442Potassium cyanate

Product 1

HCID 971246212-32-4

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

15.0 g (0.11 mol) of 4-chlorobenzaldehyde, 51.3 g (0.53 mol) of ammonium carbonate and 7.6 g (0.12 mol) of potassium cyanate are stirred in 150 ml water and 150 ml methanol for 18 hours at 55° C. The solvent is distilled off, the residue dissolved in water and extracted with ethyl acetate. The combined organic extracts are dried and concentrated by evaporation.

Workup

  1. distillationThe solvent is distilled off
  2. dissolutionthe residue dissolved in water
  3. extractionextracted with ethyl acetate
  4. customThe combined organic extracts are dried
  5. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-51d9bebd23214364b3d82d00547ca45d
Source dataset
uspto-grants-2001_06
Patent number
US06248770B1

Reaction notes

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