Phenyl isocyanate → HCID 22243800, compound

HRID 1067487Notes

Reaction equation

HRID 1067487 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[N:5]=[CH:4][N:3]=1.[C:21]1([N:27]=[C:28]=[O:29])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>ClCCl>[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][C:10]2[CH:9]=[CH:8][CH:7]=[C:6]3[C:11]=2[C:2]([NH:1][C:28]([NH:27][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:29])=[N:3][CH:4]=[N:5]3)=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 22386590HCID 22386590, compound

Product 1

HCID 22243800HCID 22243800, compoundYield 64.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-Amino-5-(4-methoxyphenoxy)Quinazoline (1.0 g, 3.7 mmol) and phenyl isocyanate (0.52 g, 4.4 mmol) were reacted in 30 ml of dichloromethane according to procedure E to give 1-[5-(4-methoxyphenoxy)quinazolin-4-yl]-3-phenylurea (0.9 g, 64.3%, m.p. 231-232° C.).

Sources & evidence

ORD record
ord-9c2904f1db5f42a3866f076ebf9dbda2
Source dataset
uspto-grants-2001_06
Patent number
US06248771B1

Reaction notes

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