Sodium Hydroxide → Sodium 2-[6-[3-[4-(diphenylmethoxy) piperidino]propylamino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate
Reaction equation
[C:1]1([CH:7]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]3[CH:20]=[CH:21][C:22]4[N:23]([CH:25]=[C:26]([C:28]([CH3:33])([CH3:32])[C:29]([OH:31])=[O:30])[N:27]=4)[N:24]=3)[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+:41]>CO.CC(O)C>[C:34]1([CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[O:8][CH:9]2[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]3[CH:20]=[CH:21][C:22]4[N:23]([CH:25]=[C:26]([C:28]([CH3:33])([CH3:32])[C:29]([O-:31])=[O:30])[N:27]=4)[N:24]=3)[CH2:13][CH2:14]2)[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1.[Na+:41]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of 2-[6-[3-[4-(diphenylmethoxy) piperidino]propylamino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid (528 mg) in methanol (2 ml), a 2 N aqueous solution of sodium hydroxide (0.47 ml) was added, followed by stirring at room temperature for 5 minutes. This solution was diluted with 2-propanol and concentrated under reduced pressure; the residue was dissolved in 2-propanol and again concentrated under reduced pressure. To this residue, 2-propanol and ethyl ether were added; the resulting powder was collected by filtration to yield the title compound (474 mg).
Workup
- concentrationconcentrated under reduced pressure
- dissolutionthe residue was dissolved in 2-propanol
- concentrationagain concentrated under reduced pressure
- additionTo this residue, 2-propanol and ethyl ether were added
- filtrationthe resulting powder was collected by filtration
Sources & evidence
- ORD record
- ord-782a2b9ad1964212aefa7d90e6754b80
- Source dataset
- uspto-grants-2001_06
- Patent number
- US06248740B1
Reaction notes
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