反应详情

温度

70 °C

1.42 g of 4-(diphenylmethoxy)-1-piperidinepropanamine and 929 mg of methyl (6-chloro[1,2,4]triazolo[1,5-b]pyridazin-7-yl)carboxylate were dissolved in 20 ml of N,N-dimethylformamide; 1.51 ml of N-ethyldiisopropylamine was added, followed by stirring at 70° C. for 6 hours. After cooling, water was added; the mixture was saturated with sodium chloride and extracted with ethyl acetate-tetrahydrofuran (1:1); the extract was dried with magnesium sulfate. The dry product was concentrated under reduced pressure; the residue was subjected to silica gel column chromatography and eluted with ethyl acetate:methanol:triethylamine (50:5:1). The desired fraction was collected and concentrated; the residue was crystallized by the addition of ethyl acetate-ethyl ether-hexane (1:2:1), collected by filtration, washed with hexane and dried to yield 905 mg of the title compound.

1. temperatureAfter cooling
2. extractionextracted with ethyl acetate-tetrahydrofuran (1:1)
3. dry with materialthe extract was dried with magnesium sulfate
4. concentrationThe dry product was concentrated under reduced pressure
5. washeluted with ethyl acetate:methanol:triethylamine (50:5:1)
6. customThe desired fraction was collected
7. concentrationconcentrated
8. customthe residue was crystallized by the addition of ethyl acetate-ethyl ether-hexane (1:2:1)
9. filtrationcollected by filtration
10. washwashed with hexane
11. customdried