Sodium Hydroxide → HCID 11746720, compound

HRID 1067585Notes

Reaction equation

HRID 1067585 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([CH3:17])([CH3:16])[C:12]([O:14]C)=[O:13])[N:10]=2)[N:7]=1.[OH-].[Na+]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([CH3:17])([CH3:16])[C:12]([OH:14])=[O:13])[N:10]=2)[N:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11075988HCID 11075988, compound

Product 1

HCID 11746720HCID 11746720, compoundYield 80.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.40 g of methyl 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2-methylpropionate was dissolved in 15 ml of tetrahydrofuran; 9 ml of a 1 N aqueous solution of sodium hydroxide was added, followed by stirring at room temperature for 3 hours. After the mixture was concentrated under reduced pressure, the residue was ajusted to pH 4 by the addition of 1 N hydrochloric acid; the crystal precipitated was collected by filtration to yield 1.06 g of the title compound.

Workup

  1. concentrationAfter the mixture was concentrated under reduced pressure
  2. additionthe residue was ajusted to pH 4 by the addition of 1 N hydrochloric acid
  3. customthe crystal precipitated
  4. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-fbc17d51c48a4ace86d85166b36975db
Source dataset
uspto-grants-2001_06
Patent number
US06248740B1

Reaction notes

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