Hydrochloric Acid → HCID 9879640, compound

HRID 1067651Notes

Reaction equation

HRID 1067651 reaction equation
C([O:3][C:4]([C:6]1[C:11]2[CH:12]=[C:13]([C:16]([F:19])([F:18])[F:17])[CH:14]=[CH:15][C:10]=2[O:9][C:8]([CH2:22][F:23])([CH2:20][F:21])[CH:7]=1)=[O:5])C.[OH-].[K+].Cl>C(O)C>[F:23][CH2:22][C:8]1([CH2:20][F:21])[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[C:11]2[CH:12]=[C:13]([C:16]([F:19])([F:17])[F:18])[CH:14]=[CH:15][C:10]=2[O:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19037095ethyl 2,2-bisfluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carboxylate

Product 1

HCID 9879640HCID 9879640, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 0.51 g of 2,2-bisfluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carboxylic acid ethyl ester, 0.13 g of potassium hydroxide and 10 ml of ethyl alcohol was stirred at room temperature for 2 hours. The reaction mixture was combined with ice water and hydrochloric acid, and the precipitated crystals were filtered off to give 0.43 g of 2,2-bisfluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carboxylic acid; m.p. 162-163° C.;

Workup

  1. filtrationthe precipitated crystals were filtered off

Sources & evidence

ORD record
ord-303a4b828b864cc287f3a7855071142c
Source dataset
uspto-grants-2001_06
Patent number
US06248777B1

Reaction notes

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