Ethanol → HCID 178465688, compound

HRID 1067693Notes

Reaction equation

HRID 1067693 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16](=O)[CH3:17])=[CH:12][CH:11]=2)[N:3]=[CH:2]1.Cl.[NH2:20][OH:21].[OH-].[Na+].C(O)C>O>[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16](=[N:20][OH:21])[CH3:17])=[CH:12][CH:11]=2)[N:3]=[CH:2]1

Participants

6

Reactant 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 178466793HCID 178466793, compound

Product 1

HCID 178465688HCID 178465688, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.2 mmol of (4-(3-(1H-imidazol-4-yl)propyloxy)phenyl)ethanone (Example 78), 2.4 mmol of hydroxylamine hydrochloride and 4.8 mmol of NaOH are heated under reflux in 10 ml of water and 10 ml of ethanol for 7 hours. The mixture is concentrated under reduced pressure and alkalized with saturated K2CO3 solution, and the crude product is filtered off and washed with water. The product is crystallized as hydrogen maleate from diethyl ether and ethanol.

Workup

  1. concentrationThe mixture is concentrated under reduced pressure
  2. filtrationthe crude product is filtered off
  3. washwashed with water
  4. customThe product is crystallized as hydrogen maleate from diethyl ether and ethanol

Sources & evidence

ORD record
ord-5d64a911aa25410c9dc100872180861d
Source dataset
uspto-grants-2001_06
Patent number
US06248765B1

Reaction notes

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