Methanol → HCID 21194070, compound

HRID 1067808Notes

Reaction equation

HRID 1067808 reaction equation
[OH:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[C:11]([OH:13])=[O:12].S(Cl)(Cl)=O.[CH3:18]O>>[OH:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[C:11]([O:13][CH3:18])=[O:12]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 211941991-Hydroxy-1H-indole-2-carboxylic acid

Product 1

HCID 21194070HCID 21194070, compoundYield 59.5%

Procedure

The reaction was carried out in a manner similar to Reference Example 6 except for using 3.99 g (22.5 mmol) of 1-hydroxy-2-indolecarboxylic acid, 5.36 g (45.0 mmol) of thionyl chloride and 100 ml of methanol. Thus 2.56 g (59.5%) of methyl 1-hydroxy-2-indolecarboxylate was obtained.

Sources & evidence

ORD record
ord-16e47818614d4b14b93d6da71617f7e6
Source dataset
uspto-grants-2001_06
Patent number
US06248772B1

Reaction notes

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