Guanidine Hydrochloride → HCID 178485135, compound

HRID 1067814Notes

Reaction equation

HRID 1067814 reaction equation
C[N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[NH:11][C:12](=[O:21])[CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=[C:3]1[C:22]([O:24]CC)=O.[ClH:27].[NH2:28][C:29]([NH2:31])=[NH:30].[CH3:32][O-].[Na+]>CO>[ClH:27].[CH3:32][NH:30][C:29]([NH2:31])=[N:28][C:22]([C:3]1[NH:2][C:10]2[C:5]([CH:4]=1)=[CH:6][CH:7]=[CH:8][C:9]=2[NH:11][C:12](=[O:21])[CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:24]

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 21194158HCID 21194158, compound

Product 1

HCID 178485135HCID 178485135, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction was carried out in a manner similar to Example 1 except for using 0.42 g (1.21 mmol) of ethyl 1-methyl-7-(3-phenylpropionamido)-2-indolecarboxylate, 2.31 g (24.2 mmols) of guanidine hydrochloride and a solution of 1.31 g (24.2 mmols) of sodium methoxide in 30 ml of methanol. 1-Methyl-7-(3-phenylpropionamido)-2-indoloylguanidine hydrochloride was obtained in an amount of 0.16 g (34.9%).

Sources & evidence

ORD record
ord-bde706638a704a37be8d30a9cb6de514
Source dataset
uspto-grants-2001_06
Patent number
US06248772B1

Reaction notes

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