Guanidine Hydrochloride → HCID 178485131, compound

HRID 1067818Notes

Reaction equation

HRID 1067818 reaction equation
C[N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[NH:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:4]=[C:3]1[C:20]([O:22]CC)=O.[ClH:25].[NH2:26][C:27]([NH2:29])=[NH:28].[CH3:30][O-].[Na+]>CO>[ClH:25].[CH3:30][NH:28][C:27]([NH2:29])=[N:26][C:20]([C:3]1[NH:2][C:10]2[C:5]([CH:4]=1)=[CH:6][CH:7]=[CH:8][C:9]=2[NH:11][CH2:12][CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:22]

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 21194741Ethyl 1-methyl-7-(2-phenylethylamino)-2-indolecarboxylate

Product 1

HCID 178485131HCID 178485131, compoundYield 39.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 0.16 g (0.51 mmol) of ethyl 1-methyl-7-(2-phenylethylamino)-2-indolecarboxylate, 0.49 g (5.09 mmol) of guanidine hydrochloride and 0.28 g (5.09 mmol) of sodium methoxide in 10 ml of methanol was reacted in a manner similar to Example 1 to give 0.075 g (39.5%) of 1-methyl-7-(2-phenylethylamino)-2-indoloylguanidine hydrochloride.

Workup

  1. customwas reacted in a manner similar to Example 1

Sources & evidence

ORD record
ord-9b3bc823460841b0bc084c7fb21287c1
Source dataset
uspto-grants-2001_06
Patent number
US06248772B1

Reaction notes

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