Guanidine Hydrochloride → HCID 178485144, compound

HRID 1067843Notes

Reaction equation

HRID 1067843 reaction equation
C(OC([NH:8][CH2:9][C:10]1[CH:33]=[CH:32][C:13]([CH2:14][O:15][C:16]2[CH:17]=[CH:18][C:19]([Cl:31])=[C:20]3[C:24]=2[N:23](C)[C:22]([C:26]([O:28]CC)=O)=[CH:21]3)=[CH:12][CH:11]=1)=O)(C)(C)C.[ClH:34].[NH2:35][C:36]([NH2:38])=[NH:37].[CH3:39][O-].[Na+]>CO>[ClH:31].[ClH:34].[NH2:8][CH2:9][C:10]1[CH:33]=[CH:32][C:13]([CH2:14][O:15][C:16]2[CH:17]=[CH:18][C:19]([Cl:31])=[C:20]3[C:24]=2[NH:23][C:22]([C:26]([N:37]=[C:36]([NH2:38])[NH:35][CH3:39])=[O:28])=[CH:21]3)=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 21194287HCID 21194287, compound

Product 1

HCID 178485144HCID 178485144, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction was carried out in a manner similar to Example 196 e) except for using 0.60 g (1.27 mmol) of ethyl 7-[4-(tert-butoxycarbonylaminomethyl)-benzyloxy]-4-chloro-1-methyl-2-indolecarboxylate, 2.42 g (25.4 mmol) of guanidine hydrochloride, 1.37 g (25.4 mmol) of sodium methoxide and 50 ml of methanol. Thus, 0.25 9 (43.0%) of 7-[4-(aminomethyl)benzyloxy]-4-chloro-1-methyl-2-indoloylguanidine dihydrochloride was obtained.

Sources & evidence

ORD record
ord-66cddc2973734f728a4f7707b19a10fd
Source dataset
uspto-grants-2001_06
Patent number
US06248772B1

Reaction notes

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