Guanidine Hydrochloride → HCID 178485145, compound

HRID 1067845Notes

Reaction equation

HRID 1067845 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][N:20]([CH3:22])[CH3:21])=[CH:15][CH:14]=2)=[C:7]2[C:3]=1[CH:4]=[C:5]([C:24]([O:26]CC)=O)[N:6]2C.[ClH:29].[NH2:30][C:31]([NH2:33])=[NH:32].[CH3:34][O-].[Na+]>CO>[ClH:1].[ClH:29].[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][N:20]([CH3:22])[CH3:21])=[CH:15][CH:14]=2)=[C:7]2[C:3]=1[CH:4]=[C:5]([C:24]([N:32]=[C:31]([NH2:33])[NH:30][CH3:34])=[O:26])[NH:6]2

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 21194301HCID 21194301, compound

Product 1

HCID 178485145HCID 178485145, compoundYield 58.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction was carried out in a manner similar to Example 186 b) except for using 0.28 g (0.70 mmol) of ethyl 4-chloro-7-[4-(dimethylaminomethyl)-benzyloxy]-1-methyl-2-indolecarboxylate, 1.52 g (16.0 mmol) of guanidine hydrochloride, 0.86 g (16.0 mmol) of sodium methoxide and 40 ml of methanol. Thus, 0.10 g (29.3%) of 4-chloro-7-[4-(dimethylaminomethyl)-benzyloxy]-1-methyl-2-indoloylguanidine dihydrochloride was obtained.

Sources & evidence

ORD record
ord-b592de8fc5ac4fd1907989e79743458e
Source dataset
uspto-grants-2001_06
Patent number
US06248772B1

Reaction notes

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