反应详情

Acetyl trifluoroacetate was prepared by the method of Bourne in which equimolar amounts of Ac2O and TFAA are combined and heated to reflux for an hour, then fractionally distilled and the material boiling between 90-100° C. collected and characterized by IR and NMR: 1H NMR (CDCl3): δ 2.39 ppm; 13C NMR (CDCl3): δ 162.7,158.7 (q, JCF=44.7 Hz), 113.9 (q, JCF=286.3 Hz), 22.0 ppm; IR (CH2Cl2) VC═O=1854,1782; vC—O—C=1075 cm−1.

1. temperatureheated
2. temperatureto reflux for an hour
3. distillationfractionally distilled
4. customboiling between 90-100° C.
5. customcollected