Ammonium formate → (3R,4S)-3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-phenylpyrrolidine

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Reaktionsgleichung

C([N:8]1[CH2:12][C@H:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C@@H:10]([CH2:19][O:20][Si:21]([C:24]([CH3:27])([CH3:26])[CH3:25])([CH3:23])[CH3:22])[CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>CO.[OH-].[OH-].[Pd+2]>[Si:21]([O:20][CH2:19][C@@H:10]1[C@@H:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:12][NH:8][CH2:9]1)([C:24]([CH3:27])([CH3:26])[CH3:25])([CH3:23])[CH3:22]

Komponenten

Reaktionsbedingungen

Temperatur: 55 °C

Versuchsvorschrift

A mixture of 117 g (0.31 mol) of 1-benzyl-3-(R)-(t-butyldimethylsilyloxymethyl)4-(S)-phenyl pyrrolidine (from Step D), 31.5 g (0.50 mol) ammonium formate, 20.0 g of 20% palladium hydroxide on carbon in 1.5 L of MeOH was heated at 55° C. for 2.5 h. The mixture was cooled and filtered through a pad of Celite. The filtrate was concentrated. The residue was dissolved in 1 L of CH2Cl2, washed with 300 mL of 10% NH4OH solution, 200 mL of sat'd NaCl, dried over MgSO4 and concentrated to afford 89.2 g (99%) of the title compound: 1H NMR (400 MHz) δ-0.09 (s, 3H), −0.08 (s, 3H), 0.77 (s, 9H), 2.25-2.30 (m, 1H), 2.84-2.96 (4H), 3.18 (dd, J=11.2, 3.2, 1H), 3.29-3.36 (m, 1H), 3.44 (dd, J=10.0, 6.0), 3.56 (dd, J=10.0, 4.4, 1H); ESI-MS 292 (M+H); HPLC A: 3.44 min.

Aufarbeitung

temperatureThe mixture was cooled
filtrationfiltered through a pad of Celite
concentrationThe filtrate was concentrated
dissolutionThe residue was dissolved in 1 L of CH2Cl2
washwashed with 300 mL of 10% NH4OH solution, 200 mL of sat'd NaCl
dry with materialdried over MgSO4
concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag: ord-7e36400198ff41929456c75bcbde2408
Quelldatensatz: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06248755B1

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