HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium formate → 1-Piperidin-4-yl-5-fluoro-1-H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 1-(1-Benzyl-piperidin-4-yl)-5-fluoro-1-H-benzoimidazole | HCID 21193025 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Piperidin-4-yl-5-fluoro-1-H-benzoimidazole | HCID 21193111 | 109.4% |
Reaction Steps
The title compound was prepared from 120 mg of 1-(1-benzyl-piperidin-4-yl)-5-fluoro-1-H-benzoimidazole (from Step B), 120 mg of 10% palladium on carbon and 120 mg ammonium formate in 5 mL of MeOH, using a procedure analogous to that described in Example 95, Step C to provide 93 mg of the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06248755B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-820f5e984aec4927ac28adb484396b25 |
| Source note | uspto-grants-2001_06 |