Ammonium formate → 1-Piperidin-4-yl-5-fluoro-1-H-benzoimidazole

HRID 1068164Notes

Reaction equation

HRID 1068164 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:18]3[CH:19]=[CH:20][C:21]([F:23])=[CH:22][C:17]=3[N:16]=[CH:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>[Pd].CO>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:18]3[CH:19]=[CH:20][C:21]([F:23])=[CH:22][C:17]=3[N:16]=[CH:15]2)[CH2:12][CH2:13]1

Participants

5

Reactant 2

HCID 2723923Ammonium formateHCID 211930251-(1-Benzyl-piperidin-4-yl)-5-fluoro-1-H-benzoimidazole

Product 1

HCID 211931111-Piperidin-4-yl-5-fluoro-1-H-benzoimidazoleYield 109.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The title compound was prepared from 120 mg of 1-(1-benzyl-piperidin-4-yl)-5-fluoro-1-H-benzoimidazole (from Step B), 120 mg of 10% palladium on carbon and 120 mg ammonium formate in 5 mL of MeOH, using a procedure analogous to that described in Example 95, Step C to provide 93 mg of the title compound as a solid.

Sources & evidence

ORD record
ord-820f5e984aec4927ac28adb484396b25
Source dataset
uspto-grants-2001_06
Patent number
US06248755B1

Reaction notes

Loading…