HRID1068174

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID667423

Benzyl (2S)-hydroxy(phenyl)acetate

C15H14O3

结构：CC(C)(C)[Si](C)(C)OC[C@H]1CNC[C@@H]1c1ccccc1

HCID21341073

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)OC[C@@H]1CN(C(C(=O)OCc2ccccc2)c2ccccc2)C[C@@H]1c1ccccc1

HCID131722693

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 3-(R)-(t-butyldimethylsilyloxymethyl)-4-(S)-phenyl pyrrolidine (prepared above as Pyrrolidine 1) and (S)-mandelic acid, benzyl ester using a procedure analogous to that described in the preparation given above of Aldehyde 1. The title compound was obtained as a mixture of diastereomers: RF: 0.68 (4:1 v/v hexanes/EtOAc).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-98241611234b4ce492271f2504dec204
来源数据集: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06248755B1
来源说明: uspto-grants-2001_06

反应 SMILES

[Si:1]([O:8][CH2:9][C@@H:10]1[C@@H:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:13][NH:12][CH2:11]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[C:21]([O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)(=[O:30])[C@H:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)O>>[Si:1]([O:8][CH2:9][C@H:10]1[C@@H:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:13][N:12]([CH:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:21]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[O:30])[CH2:11]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]