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Benzyl (2S)-hydroxy(phenyl)acetate → 2-(R/S)-(3-(S)-(t-Butyldimethylsilyloxymethyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(phenyl)acetic acid, benzyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl (2S)-hydroxy(phenyl)acetate | HCID 667423 | — |
| 反応物 | (3R,4S)-3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-phenylpyrrolidine | HCID 21341073 | — |
| 生成物 | 2-(R/S)-(3-(S)-(t-Butyldimethylsilyloxymethyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(phenyl)acetic acid, benzyl ester | HCID 131722693 | — |
反応手順
The title compound was prepared from 3-(R)-(t-butyldimethylsilyloxymethyl)-4-(S)-phenyl pyrrolidine (prepared above as Pyrrolidine 1) and (S)-mandelic acid, benzyl ester using a procedure analogous to that described in the preparation given above of Aldehyde 1. The title compound was obtained as a mixture of diastereomers: RF: 0.68 (4:1 v/v hexanes/EtOAc).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06248755B1 |
| 出典データセット | uspto-grants-2001_06 |
| ORD ID | ord-98241611234b4ce492271f2504dec204 |
| 出典メモ | uspto-grants-2001_06 |