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Ethyl acetylphenylacetate → 1-benzyl-4-(5-methyl-4-phenyl-1H-pyrazol-3(2H)-on-2-yl)-piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl acetylphenylacetate | HCID 95389 | — |
| 反応物 | 1-Benzyl-4-hydrazinylpiperidine | HCID 416192 | — |
| 生成物 | 1-benzyl-4-(5-methyl-4-phenyl-1H-pyrazol-3(2H)-on-2-yl)-piperidine | HCID 21193008 | 77.7% |
反応手順
When 1.4 g of 1-benzyl-4-hydrazinopiperidine and 2.0 g of ethyl 2-phenylacetoacetate were used in the procedure of Example 124, Step A, there was obtained 1.84 g of 1-benzyl-4-(5-methyl-4-phenyl-1H-pyrazol-3(2H)-on-2-yl)-piperidine. ESI-MS 348.2 (M+H); HPLC A: 1.95 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06248755B1 |
| 出典データセット | uspto-grants-2001_06 |
| ORD ID | ord-6b6f85e942f0422aa208a71f679d55cb |
| 出典メモ | uspto-grants-2001_06 |