Hydrochloric Acid → HCID 70108790, compound

HRID 1068189Notes

Reaction equation

HRID 1068189 reaction equation
[CH2:1]([C:8]1[S:12][C:11]([CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)=[N:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:26]>CO>[ClH:26].[CH2:1]([C:8]1[S:12][C:11]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[N:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21193040HCID 21193040, compound

Product 1

HCID 70108790HCID 70108790, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 37 mg of 4-(5-benzyl-thiazol-2-yl)-1-t-butyloxycarbonyl-piperidine (from Step B) was added 4 ml of a saturated solution of hydrochloric acid in methanol. The reaction was stirred for 3.5 hours at room temperature. The methanol was evaporated under reduced pressure to give 24 mg of the title compound. ESI-MS 259 (M+H); HPLC A: 2.00 min.

Workup

  1. customThe methanol was evaporated under reduced pressure

Sources & evidence

ORD record
ord-d9e587331de241beb15087ad97b57cbb
Source dataset
uspto-grants-2001_06
Patent number
US06248755B1

Reaction notes

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