Acetyl chloride → HCID 20481135, compound

HRID 1068210Notes

Reaction equation

HRID 1068210 reaction equation
C([Cl:4])(=O)C.C(OC([N:12]1[CH2:17][CH2:16][CH:15]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH:19]=2)[CH2:14][CH2:13]1)=O)(C)(C)C>CO>[ClH:4].[CH2:24]([C:20]1[CH:19]=[C:18]([CH:15]2[CH2:16][CH2:17][NH:12][CH2:13][CH2:14]2)[CH:23]=[CH:22][CH:21]=1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 54497640HCID 54497640, compound

Product 1

HCID 20481135HCID 20481135, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 2 mL of MeOH at 0° C. was added 0.17 mL of acetyl chloride. After warming to room temperature and stirring for 15 minutes, a solution of 71 mg (0.20 mmol) of 1-tert-butoxycarbonyl-4-((3-benzyl)phenyl)-piperidine (from Step E) was added. The reaction was stirred for 1 hour at room temperature. Volatiles were removed under reduced pressure to yield the title compound, which was used without further purification.

Workup

  1. stirringThe reaction was stirred for 1 hour at room temperature
  2. customVolatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-4336d4c9e7b7451588a72dda820f66af
Source dataset
uspto-grants-2001_06
Patent number
US06248755B1

Reaction notes

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