Hydrochloric Acid → HCID 21193020, compound

HRID 1068236Notes

Reaction equation

HRID 1068236 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[S:18][C:17]([C:19](=[O:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CO>[C:19]([C:17]1[S:18][C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:15][N:16]=1)(=[O:26])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21192984HCID 21192984, compound

Product 1

HCID 21193020HCID 21193020, compoundYield 111.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 11 mg of 1-t-butyloxycarbonyl-4-(2-benzoyl-thiazol-5-yl)piperidine (step A) was added 1.5 ml of saturated HCl in MeOH. The reaction was stirred at room temperature overnight. The solvent was evaporated under reduced pressure to give 9 mg of the title compound.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-954754c6a1bd48e8996548c06b0aa723
Source dataset
uspto-grants-2001_06
Patent number
US06248755B1

Reaction notes

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