Hydrochloric Acid → HCID 70126387, compound

Participants

Reaction Steps

Acetyl chloride (0.2 mL, 2.8 mmol) was added to 2 mL of methanol and stirred for 10 min. This solution of HCl in methanol was added to 46 mg of 4-(5-benzyl-1,2,4-thiadiazol-2-yl)-1-t-butyoxycarbonyl-pieridine (step B) and stirred for 1 hr. The reaction mixture was concentrated and the residue was diluted with EtOAc and concentrated again to isolate 46 mg of the title compound which was sufficiently pure for use in the next step.

Provenance & Evidence